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Related Experiment Videos

Zinc exposure in Chinese foundry workers.

C J Martin1, X C Le, T L Guidotti

  • 1Department of Public Health Sciences, Faculty of Medicine, University of Alberta, Edmonton, Canada.

American Journal of Industrial Medicine
|May 20, 1999
PubMed
Summary

Workers exposed to high levels of zinc oxide fumes did not develop metal fume fever. Urinary zinc levels correlated with exposure, suggesting urine is a useful biomarker for zinc exposure.

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Area of Science:

  • Occupational Health
  • Environmental Toxicology
  • Industrial Hygiene

Background:

  • Inhalational exposure to zinc oxide fumes can cause metal fume fever, an influenza-like illness.
  • Understanding zinc toxicokinetics is crucial for interpreting biological monitoring data.
  • Current knowledge on inhaled zinc toxicokinetics is limited, complicating exposure assessment.

Purpose of the Study:

  • To investigate the relationship between zinc exposure and metal fume fever in foundry workers.
  • To assess the utility of serum and urine zinc levels as biomarkers of exposure.
  • To establish exposure thresholds for tolerance to metal fume fever.

Main Methods:

  • Studied 20 zinc foundry workers in China.
  • Conducted serial physician examinations, chest radiographs, and spirometry.

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  • Measured zinc in serum, urine, and personal air samples.

    • Main Results:

    • No cases of metal fume fever were observed despite high zinc fume exposures (up to 36.3 mg/m3).
    • Serum zinc levels remained within the reference range and did not correlate with exposure.
    • Elevated urinary zinc levels showed a significant association with zinc exposure (r=0.47, P=0.04).

    Conclusions:

    • Identified zinc exposure levels at which workers tolerate metal fume fever.
    • Urinary zinc appears to be a preferred biomarker for assessing zinc exposure.
    • Findings contribute to understanding occupational health risks in zinc foundries.