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Related Experiment Videos

Ototoxicity associated with vinblastine.

P E Moss1, S Hickman, B R Harrison

  • 1St. Louis College of Pharmacy, MO, USA.

The Annals of Pharmacotherapy
|May 20, 1999
PubMed
Summary

This case study highlights potential ototoxicity from vinblastine chemotherapy. Tinnitus and hearing loss were observed in a patient receiving ABVD treatment, suggesting vinblastine as a possible cause.

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Area of Science:

  • Oncology
  • Ototoxicology
  • Pharmacology

Background:

  • Chemotherapy regimens like ABVD are standard for Hodgkin's disease.
  • Vinca alkaloids are commonly used in cancer treatment.
  • Ototoxicity is a known side effect of some chemotherapy agents.

Observation:

  • A patient undergoing ABVD chemotherapy for Hodgkin's disease experienced tinnitus and mild sensorineural hearing loss.
  • Symptoms of tinnitus began approximately six hours after each treatment cycle and lasted several days.
  • Audiograms confirmed high-frequency hearing loss, though speech recognition remained intact.

Findings:

  • The patient's ototoxicity symptoms were temporally associated with vinblastine administration within the ABVD regimen.
  • No other medications were identified as the cause of the observed ototoxicity.
  • Literature review revealed no prior reports of ototoxicity specifically linked to the ABVD regimen.

Implications:

  • This case suggests a potential ototoxic effect of vinblastine, a vinca alkaloid.
  • Further investigation into vinblastine-induced ototoxicity is warranted.
  • Clinicians should monitor for auditory side effects in patients receiving vinblastine-containing chemotherapy.

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