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Related Experiment Videos

Allergic-type reactions to corticosteroids.

G L Kamm1, K O Hagmeyer

  • 1College of Pharmacy, University of Toledo, OH 43606, USA. gkamm@pop3.utoledo.edu

The Annals of Pharmacotherapy
|May 20, 1999
PubMed
Summary

Allergic reactions to corticosteroids, while uncommon, can range from mild rashes to life-threatening anaphylaxis. Clinicians must recognize these potential adverse events, especially in high-risk patients, and consider skin testing for alternative corticosteroid options.

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Area of Science:

  • Immunology
  • Pharmacology
  • Clinical Medicine

Background:

  • Corticosteroids are widely used to manage inflammatory and allergic conditions.
  • Paradoxically, patients can develop allergic-type reactions to corticosteroids themselves.

Observation:

  • This review synthesizes case reports on allergic-type reactions to systemically administered corticosteroids.
  • Reactions vary in severity from dermatological symptoms to anaphylaxis and death.
  • Both immediate and delayed hypersensitivity responses have been documented.

Findings:

  • Methylprednisolone and hydrocortisone are frequently implicated corticosteroids.
  • Asthma patients and renal transplant recipients show a higher incidence of these reactions.
  • The precise immunological mechanisms underlying these reactions remain under investigation.

Implications:

  • Clinicians must consider allergic reactions when corticosteroid treatment appears ineffective or worsens.
  • Careful administration of high-dose corticosteroids and post-administration monitoring are recommended.
  • Intradermal skin testing may aid in identifying cross-reactivity and selecting alternative corticosteroids.

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