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Immunological cross reactivity between Candida albicans and human tissue
A Vojdani1, P Rahimian, H Kalhor
1Immunsciences Lab Inc., Beverley Hills, CA 90211, USA.
Journal of Clinical & Laboratory Immunology
|January 1, 1996
Summary
This study reveals molecular mimicry between Candida and human tissues, suggesting a potential role for Candida in autoimmune diseases. Elevated Candida antibodies were found in patients with tissue autoantibodies, indicating cross-reactivity.
Area of Science:
- Immunology
- Microbiology
- Autoimmunity
Background:
- Autoimmune diseases are often linked to molecular mimicry, where exogenous agents share determinants with self-antigens.
- Investigating cross-reactivity between Candida and human autoantigens may elucidate mechanisms of autoimmunity.
Purpose of the Study:
- To explore molecular mimicry between Candida albicans and human autoantigens.
- To determine if Candida antibodies are elevated in individuals with autoantibodies against thyroid, ovary, or adrenal tissues.
Main Methods:
- Sera from patients with and without tissue autoantibodies were screened for Candida IgG, IgM, and IgA antibodies.
- Immunodiffusion and Western Blot assays were used to assess cross-reactivity between Candida and human tissue antigens.
- Absorption studies were performed to quantify the reduction in antibody titers upon antigen exposure.
Main Results:
- Patients with tissue autoantibodies showed significantly higher levels of Candida antibodies compared to controls.
- Western Blot analysis identified common antigens between Candida and human tissues at 72 and 36 KD.
- Absorption of sera with tissue antigens or treatment with C. Albicans reduced antibody titers, supporting cross-reactivity.
Conclusions:
- Demonstrates immunological cross-reactivity between Candida albicans and human tissues.
- Suggests a potential pathogenic role for Candida albicans in the development of autoimmune diseases.
- Highlights the need for further investigation into Candida's role in autoimmunity.