Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is there a glycemic threshold for mortality risk?

B Balkau1, S Bertrais, P Ducimetiere

  • 1Institut National de la Santé et de la Recherche Médicale (INSERM) U258, Villejuif, France. balkau@vjf.inserm.fr

Diabetes Care
|May 20, 1999
PubMed
Summary

This study found no specific glucose thresholds that sharply increase mortality risk. Instead, higher fasting and 2-hour glucose levels progressively elevate the risk of death from all causes and coronary heart disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased risk of type 2 diabetes in antidepressant users: evidence from a 6-year longitudinal study in the E3N cohort.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Learning about diabetes through epidemiology.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort.

Diabetes & metabolism·2019
Same author

Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study.

Diabetes & metabolism·2018
Same author

Determinants of 20-year non-progression to Type 2 diabetes in women at very high risk: the E3N cohort study.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Haemoglobin A1c and 5-year all-cause mortality in French type 2 diabetic patients aged 70 years and older: The GERODIAB observational cohort.

Diabetes & metabolism·2018

Area of Science:

  • Cardiovascular Epidemiology
  • Metabolic Health Research

Background:

  • Elevated glucose levels are a known risk factor for cardiovascular disease and mortality.
  • Identifying specific glucose thresholds is crucial for risk stratification and early intervention.

Purpose of the Study:

  • To investigate if distinct thresholds exist for fasting and 2-hour glucose concentrations above which all-cause and coronary heart disease (CHD) mortality risk escalates.
  • To analyze the relationship between glucose levels and mortality in a cohort of middle-aged men.

Main Methods:

  • Utilized 23-year mortality data from the Paris Prospective Study, including 7,018 non-diabetic men aged 44-55 at baseline.
  • Employed observed relative risks and an age-adjusted Cox proportional hazards model to assess glucose concentration effects on mortality.

Related Experiment Videos

Main Results:

  • Observed J-shaped relationships between all-cause mortality and both fasting (lowest rates ~5.5 mmol/l) and 2-hour glucose (lowest rates ~5.0 mmol/l).
  • For CHD mortality, fasting glucose showed a positive linear relationship, while 2-hour glucose exhibited a J-shaped curve (lowest rates ~6.0 mmol/l).

Conclusions:

  • No distinct glucose thresholds were identified that trigger a sharp increase in mortality.
  • Progressive increases in fasting and 2-hour glucose concentrations are associated with a gradually rising risk of death.