Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural basis for membrane fusion by enveloped viruses.

W Weissenhorn1, A Dessen, L J Calder

  • 1Laboratory of Molecular Medicine, Children's Hospital, Boston, MA 02215, USA. weissen@embl-grenoble.fr

Molecular Membrane Biology
|May 20, 1999
PubMed
Summary

This review explores viral envelope glycoproteins, focusing on HIV-1 gp41. It reveals conserved structural strategies across diverse enveloped viruses, proposing a general model for viral membrane fusion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2017
Same author

Resistance to antibiotics targeted to the bacterial cell wall.

Protein science : a publication of the Protein Society·2013
Same author

Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.

Virus research·2013
Same author

Solution X-ray scattering study of a full-length class A penicillin-binding protein.

Biochemical and biophysical research communications·2011
Same author

Structural basis for oseltamivir resistance of influenza viruses.

Vaccine·2009
Same author

Avian and human receptor binding by hemagglutinins of influenza A viruses.

Glycoconjugate journal·2006

Area of Science:

  • Virology
  • Structural Biology
  • Molecular Biology

Background:

  • Enveloped viruses like HIV-1, influenza, and Ebola utilize surface glycoproteins for cell entry.
  • These glycoproteins mediate viral attachment and the critical fusion of viral and host cell membranes.
  • Membrane fusion releases the viral genome into the host cell, initiating infection.

Purpose of the Study:

  • To review the HIV-1 gp41 membrane fusion protein.
  • To discuss structural similarities among diverse viral fusion proteins.
  • To propose a general model for viral membrane fusion based on conserved strategies.

Main Methods:

  • Comparative structural analysis of viral membrane fusion proteins.
  • Review of existing literature on HIV-1 gp41, influenza virus, and Ebola virus fusion mechanisms.

Related Experiment Videos

  • Development of a generalized model for viral membrane fusion.

    • Main Results:

    • Viral membrane fusion proteins, despite belonging to diverse families (Retroviridae, Orthomyxoviridae, Filoviridae), exhibit conserved structural features.
    • These conserved structures suggest a common evolutionary strategy for mediating membrane fusion.
    • A general model for viral membrane fusion is proposed based on these shared mechanisms.

    Conclusions:

    • Viral envelope glycoproteins employ similar structural strategies to achieve membrane fusion.
    • The proposed general model provides a unified framework for understanding viral entry.
    • Further research into these conserved mechanisms could reveal new antiviral targets.