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Related Experiment Videos

Perphenazine-induced hiccups.

H Miyaoka, K Kamijima

    Pharmacopsychiatry
    |May 20, 1999
    PubMed
    Summary

    This study reports a rare case of severe hiccups caused by perphenazine, a dopamine antagonist. This finding highlights a potential new side effect of antidopaminergic drugs.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Hiccups are involuntary inspiratory muscle contractions causing a distinct sound.
    • Persistent hiccups can stem from various medical conditions.
    • Corticosteroids and benzodiazepines are frequently linked to drug-induced hiccups.

    Observation:

    • A case of severe hiccups developed during perphenazine administration.
    • Perphenazine is classified as a dopamine antagonist.
    • This is the first reported instance of hiccups as a side effect of antidopaminergic drugs.

    Findings:

    • Antidopaminergic drugs, specifically perphenazine, can induce severe hiccups.
    • This represents a novel side effect within the antidopaminergic drug class.

    Implications:

    • Clinicians should consider perphenazine as a potential cause of hiccups.
    • Further research is needed to understand the mechanism of antidopaminergic-induced hiccups.
    • This finding may broaden the differential diagnosis for drug-induced hiccups.