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Iatrogenic hyperadrenocorticism in 28 dogs
H P Huang1, H L Yang, S L Liang
1Department of Veterinary Medicine, National Taiwan University, Taipei.
Journal of the American Animal Hospital Association
|May 20, 1999
Summary
This study on iatrogenic hyperadrenocorticism in dogs found common signs like skin lesions and increased thirst. Withdrawal of corticosteroids led to initial improvement in six weeks and full remission in twelve weeks.
Area of Science:
- Veterinary Medicine
- Endocrinology
Background:
- Iatrogenic hyperadrenocorticism is a condition caused by excessive corticosteroid administration in dogs.
- Clinical signs and biochemical alterations are indicative of this endocrine disorder.
Purpose of the Study:
- To describe the clinical and biochemical characteristics of iatrogenic hyperadrenocorticism in dogs.
- To determine the time course for clinical improvement and remission after corticosteroid withdrawal.
Main Methods:
- A retrospective study of 28 dogs diagnosed with iatrogenic hyperadrenocorticism.
- Analysis of clinical signs, biochemical profiles, and cortisol levels following adrenocorticotropic hormone (ACTH) stimulation.
- Monitoring of clinical signs after corticosteroid withdrawal.
Main Results:
- The most frequent clinical signs included cutaneous lesions, polydipsia, polyuria, and lethargy.
- Biochemical abnormalities commonly observed were elevated alkaline phosphatase (ALP), alanine transferase (ALT), hypercholesterolemia, elevated aspartate transferase (AST), and triglycerides.
- Baseline cortisol levels were low, with suppressed responses to ACTH stimulation.
- Initial clinical improvement was observed at a mean of six weeks, with complete remission at a mean of twelve weeks post-corticosteroid withdrawal.
Conclusions:
- Iatrogenic hyperadrenocorticism presents with characteristic clinical and biochemical findings in dogs.
- Corticosteroid withdrawal is an effective treatment, with a predictable timeline for recovery.