Related Experiment Videos
Prophylactic amnioinfusion in preganancies complicated by chorioamnionitis: a prospective randomized trial
1Department of Obstetrics and Gynecology, Northwestern University Medical School and Northwestern Memorial Hospital, Chicago, Illinois, USA.
American Journal of Perinatology
|May 20, 1999
Summary
Amnioinfusion may help reduce fever in pregnant patients with chorioamnionitis. This study found amnioinfusion was associated with lower temperatures at delivery, with no identified adverse effects.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Infectious Disease in Pregnancy
Background:
- Chorioamnionitis is a common complication during pregnancy, associated with increased maternal and neonatal morbidity.
- Febrile morbidity, particularly postpartum endometritis, is a significant concern in patients with chorioamnionitis.
- Current management typically involves antibiotics and antipyretics, but adjunctive therapies are being explored.
Purpose of the Study:
- To prospectively evaluate the efficacy of amnioinfusion in reducing febrile morbidity in pregnancies complicated by chorioamnionitis.
- To assess the impact of amnioinfusion on maternal temperature at delivery and the incidence of postpartum endometritis.
- To identify any potential adverse effects associated with amnioinfusion in this patient population.
Main Methods:
- A prospective, randomized controlled trial involving laboring patients with chorioamnionitis (temperature > or =100.1°F).
- Patients were randomized to receive standard antibiotic and acetaminophen treatment with or without amnioinfusion (normal saline at 10 mL/min for 60 min, then 3 mL/min).
- Exclusion criteria included advanced dilation, multiple gestation, placental abruption, or nonreassuring fetal heart rate.
Main Results:
- Thirty-four patients (17 per group) completed the study; groups were comparable in baseline characteristics and management.
- The amnioinfusion group showed a significantly lower mean maternal temperature at delivery (99.8°F vs. 100.5°F, p=0.046).
- Incidence of postpartum endometritis was similar (3/17 in both groups), with one neonatal infection in the amnioinfusion group and none in the control group.
Conclusions:
- Prophylactic amnioinfusion in pregnancies with chorioamnionitis was associated with a reduction in maternal temperature at delivery.
- No adverse effects of amnioinfusion were identified in this study.
- Further research may be warranted to explore the role of amnioinfusion in managing chorioamnionitis and its associated febrile morbidity.