Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Embryonic stem cell models of development.

K S O'Shea1

  • 1Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109-0616, USA. oshea@umich.edu

The Anatomical Record
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder.

Advances in neurobiology·2020
Same author

Influence of copper on the early post-implantation mouse embryo: An in vivo and in vitro study.

Wilhelm Roux's archives of developmental biology·2017
Same author

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.

Translational psychiatry·2014
Same author

Dynamic changes in Wnt signaling are required for neuronal differentiation of mouse embryonic stem cells.

Molecular and cellular neurosciences·2011
Same author

Directed differentiation of embryonic stem cells: genetic and epigenetic methods.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2002
Same author

Neuronal differentiation of mouse embryonic stem cells: lineage selection and forced differentiation paradigms.

Blood cells, molecules & diseases·2001
Same journal

Gross and histological structure of the pharyngeal constrictors in the rabbit.

The Anatomical record·2014
Same journal

The amniotic duct as key to the direction of growth of the human placenta and its orientation in the uterus.

The Anatomical record·2010
Same journal

Mammary structure and secretion in premature and full-term infants.

The Anatomical record·2010
Same journal

Extrapyramidal projections from the cat's cerebral cortex.

The Anatomical record·2010
Same journal

The effect of colchicine on the rat embryo.

The Anatomical record·2010
Same journal

Lymphocytogenesis in human lymph nodes.

The Anatomical record·2010
See all related articles

Mouse embryonic stem (ES) cells allow gene function analysis in development and in vitro differentiation. This research explores their potential for cell transplantation and gene therapy applications.

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Gene Function Analysis

Background:

  • Pluripotent mouse embryonic stem (ES) cell lines are crucial tools for studying gene function during development.
  • Gene targeting in ES cells enables analysis of gene roles in developmental processes.
  • ES cells offer a model system to study lineage decisions in vitro.

Purpose of the Study:

  • To analyze gene function in development using pluripotent mouse embryonic stem (ES) cell lines.
  • To investigate the in vitro differentiation capacity of ES cells for probing gene function.
  • To explore the potential of ES cell differentiation for cell transplantation and gene therapy.

Main Methods:

  • Gene targeting in mouse embryonic stem (ES) cell lines.

Related Experiment Videos

  • In vitro differentiation assays of ES cells.
  • Analysis of lineage decisions during controlled ES cell differentiation.

    • Main Results:

    • ES cells facilitate the analysis of gene function through gene targeting.
    • In vitro differentiation of ES cells provides insights into lineage decisions.
    • Controlled differentiation yields specific cell lineages.

    Conclusions:

    • Pluripotent mouse embryonic stem (ES) cells are valuable for dissecting gene function in development.
    • In vitro differentiation of ES cells offers a model for studying developmental processes.
    • Differentiated ES cells hold promise for future cell transplantation and gene therapy strategies.