Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of variceal bleeding.

L R Roberts1, P S Kamath

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Gastrointestinal Endoscopy Clinics of North America
|May 20, 1999
PubMed
Summary

This review explains how portal hypertension causes varices and bleeding. Key factors include increased portal blood flow, vascular resistance, variceal size, and wall thickness, all influenced by portal pressure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistently Higher Ratio of Gallbladder Cancer Incidence in Native American People than in Non-Hispanic Whites: Selected United States Regions, 1962-2021.

Journal of racial and ethnic health disparities·2026
Same author

Diagnostic accuracy of Doppler Sonography of hepatic blood vessels in the detection of significant liver fibrosis: a systematic review and meta-analysis.

Journal of ultrasound·2026
Same author

First recorded presence of anthropogenic fly-ash particles in coral skeletons.

The Science of the total environment·2024
Same author

Correction to: The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.

The American journal of gastroenterology·2022
Same author

The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.

The American journal of gastroenterology·2021
Same author

Hepatocellular carcinoma: Epidemiology, pathogenesis and surveillance - implications for sub-Saharan Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2018

Area of Science:

  • Gastroenterology
  • Hepatology
  • Vascular Physiology

Background:

  • Portal hypertension is a critical complication in liver disease.
  • Understanding its pathophysiology is key to managing bleeding risks.
  • Varices are a direct consequence of elevated portal pressure.

Purpose of the Study:

  • To review the pathophysiology of variceal bleeding.
  • To discuss the pathogenesis of portal hypertension and varix formation.
  • To elucidate the factors contributing to variceal bleeding.

Main Methods:

  • Literature review of pathophysiology.
  • Discussion of contributing factors to portal hypertension.
  • Analysis of mechanisms of varix formation and bleeding.

Main Results:

  • Portal hypertension stems from increased portal flow and vascular resistance.
  • Humoral factors primarily drive increased portal blood flow.
  • Fixed and variable components contribute to portal vascular resistance.
  • Elevated portal pressure directly leads to varix formation.
  • Variceal bleeding risk correlates with portal pressure, varix size, and wall thickness.

Conclusions:

  • Variceal bleeding is a multifactorial event.
  • Management strategies should target portal pressure and varix characteristics.
  • Further research into humoral factors and resistance components is warranted.

Related Experiment Videos