Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

WT1: what has the last decade told us?

M Little1, G Holmes, P Walsh

  • 1Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia. M.Little@cmcb.uq.edu.au

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 20, 1999
PubMed
Summary

Wilms' tumour suppressor gene (WT1) mutations are linked to kidney cancer and developmental issues. Further research into WT1

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motivations for Self-Harm in Young People and Their Correlates: A Systematic Review.

Clinical child and family psychology review·2025
Same author

Examining the role of community health workers amid extreme weather events in low- and middle-income countries: a scoping review.

Public health·2024
Same author

<i>Kgaria</i> (<i>Boletaceae, Boletoideae</i>) <i>gen. nov</i>. in Australia: Neither a <i>Tylopilus</i> nor a <i>Porphyrellus</i>.

Fungal systematics and evolution·2024
Same author

Reassessing the numbers: discrepancies, implications and potential solutions for the NELA Risk Calculator.

Anaesthesia·2023
Same author

EPIC: an evaluation of the psychological impact of early-phase clinical trials in cancer patients.

ESMO open·2022
Same author

Differential attainment, socioeconomic factors and surgical training.

Annals of the Royal College of Surgeons of England·2022

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • The Wilms' tumour suppressor gene (WT1) was identified as a candidate gene for a common childhood kidney cancer.
  • WT1 encodes transcription factors involved in gene regulation, with roles in development and disease.

Purpose of the Study:

  • To review the characterization of WT1 gene expression, protein structure, and function over the past decade.
  • To explore the role of WT1 in normal development and its implication in various congenital anomalies and cancers.

Main Methods:

  • Review of WT1 gene expression patterns.
  • Analysis of WT1 protein structure, isoforms, and interactions.
  • Examination of data from knockout mice studies and human genetic analyses.

Main Results:

  • WT1 proteins function as nucleic acid-binding transcription factors, mediating both activation and repression.
  • WT1 plays a critical role in kidney and gonad development, with mutations causing urogenital anomalies.
  • WT1 mutations are found in a subset of sporadic Wilms' tumours and in other cancers like acute myeloid leukaemia.

Conclusions:

  • WT1 is a crucial developmental gene with diverse functions.
  • Future research will focus on WT1's role in RNA metabolism, protein interactions, and haematopoiesis to further elucidate its biological significance and therapeutic potential in cancers.

Related Experiment Videos