Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

5.6K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.6K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.4K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.4K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.7K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

7.0K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
7.0K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K
What is the Cell Cycle?00:56

What is the Cell Cycle?

10.6K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
10.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Redox biology·2017
Same author

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.

Oncogene·2017
Same author

Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells.

Oncogene·2012
Same author

RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.

Oncogene·2009
Same author

Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.

Oncogene·2008
Same author

Spatial control of mitosis by the GTPase Ran.

Cellular and molecular life sciences : CMLS·2007

Related Experiment Video

Updated: Feb 10, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.6K

E2F target genes and cell-cycle checkpoint control.

P Lavia1, P Jansen-Dürr

  • 1Centro di Genetica Evoluzionistica C.N.R., c/o Universita La Sapienza, Rome, Italy.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

Transcription factors of the E2F/DP family regulate gene expression critical for mammalian cell division. Dysregulation of E2F activity can lead to uncontrolled cell proliferation and cancer.

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.5K
Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
10:55

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

Published on: November 5, 2012

17.1K

Related Experiment Videos

Last Updated: Feb 10, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

1.6K
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.5K
Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
10:55

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

Published on: November 5, 2012

17.1K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The cell division cycle requires precise control of gene expression.
  • Transcription factors play a crucial role in regulating gene expression.
  • The E2F/DP family of transcription factors is implicated in cell cycle control.

Purpose of the Study:

  • To review the role of E2F/DP transcription factors in regulating cell-cycle control genes.
  • To elucidate the regulatory cascade driven by E2F/DP factors in mammalian cell division.
  • To discuss the consequences of E2F deregulation on cell cycle checkpoints and malignant transformation.

Main Methods:

  • Literature review of studies on E2F/DP transcription factors.
  • Analysis of experimental evidence on gene expression regulation during the cell cycle.
  • Examination of the impact of E2F modulation on cell proliferation and apoptosis.

Main Results:

  • E2F/DP transcription factors drive a cascade of gene expression essential for ordered cell cycle progression.
  • E2F/DP activity is regulated by the products of the genes they control, forming a feedback loop.
  • Ectopic expression of E2F family members demonstrates their potent regulatory role in cell proliferation and apoptosis.
  • Deregulation of E2F activity disrupts cell cycle checkpoints, contributing to cellular transformation.

Conclusions:

  • E2F/DP transcription factors are central regulators of the mammalian cell division cycle.
  • The precise control of E2F/DP activity is vital for maintaining genomic stability.
  • Disruption of E2F-mediated gene expression control is a key event in cancer development.