Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Saccharide-RNA recognition.

T Hermann1, E Westhof

  • 1Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France.

Biopolymers
|May 20, 1999
PubMed
Summary
This summary is machine-generated.

Aminoglycoside antibiotics are well-studied for their RNA interactions. This review surveys molecular details of how these compounds bind to RNA targets, affecting protein synthesis and ribozyme activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heavy metals in agricultural soils of the European Union with implications for food safety.

Environment international·2016
Same author

Enhanced mobilization of the bone marrow-derived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction.

Journal of cellular and molecular medicine·2011
Same author

Biopharmaceutical characterization of some new papaverine decomposition products.

Die Pharmazie·2011
Same author

Electron ionisation mass spectral study of 2-(2-carboxy-4, 5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt.

Die Pharmazie·2010
Same author

Partition coefficients of some purine derivatives and its application to pharmacokinetics.

Die Pharmazie·2010
Same author

Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata.

FEBS letters·2009
Same journal

Untreated Rosehip Powder/Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-4-Hydroxybutyrate) Electrospun Mats for Wound Dressing Applications.

Biopolymers·2026
Same journal

Synthesis, Characterization, and Antidiabetic Evaluation of Sequence-Modified Liraglutide Analogs in a Drosophila melanogaster Model.

Biopolymers·2026
Same journal

Fabrication of an Antibacterial Alginate/Chitosan Hydrogel Dressing Loaded With CuO Nanoparticles for Wound Dressing Applications.

Biopolymers·2026
Same journal

Effect of Chitosan-Alginate Polyelectrolyte Complex Formation and Multilayer Polymer Configuration on the Characteristics of 3D-Printed Metronidazole-Loaded Periodontal Films.

Biopolymers·2026
Same journal

Phenolic Grafting of Oxidized Cellulose Nanofibers Using Ferulic Acid: Structural and Antioxidant Analysis Toward Bioactive Nanomaterials.

Biopolymers·2026
Same journal

Detection of a Target Nucleic Acid by Ligation-Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding.

Biopolymers·2026
See all related articles

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Aminoglycosides are a class of saccharide antibiotics.
  • These molecules are known to interact with RNA targets.
  • Such interactions have significant biological implications.

Purpose of the Study:

  • To survey and present molecular structural data on aminoglycoside-RNA interactions.
  • To consolidate current knowledge on the binding mechanisms of aminoglycosides to RNA.

Main Methods:

  • Literature review of existing studies on aminoglycoside-RNA interactions.
  • Analysis of structural data from various experimental techniques (e.g., X-ray crystallography, NMR spectroscopy).

Main Results:

Related Experiment Videos

  • Aminoglycosides bind to specific structural motifs in RNA.
  • Binding can inhibit protein biosynthesis by interfering with ribosomal function.
  • Interactions can also affect retroviral RNA processing and ribozyme catalytic activity.

    • Conclusions:

    • Aminoglycoside-antibiotic interactions with RNA are structurally diverse.
    • Understanding these interactions is crucial for developing novel therapeutics.
    • Further structural studies will refine our knowledge of these molecular mechanisms.