Related Experiment Videos
Latanoprost and herpes simplex keratitis.
M Wand1, C M Gilbert, T J Liesegang
1Hartford Hospital, University of Connecticut School of Medicine, Farmington, USA.
American Journal of Ophthalmology
|May 20, 1999
Summary
Latanoprost eye drops may trigger herpes simplex keratitis recurrence in susceptible patients. Discontinuation of latanoprost can resolve the condition, suggesting a link between prostaglandins and herpes simplex keratitis.
Area of Science:
- Ophthalmology
- Virology
Background:
- Herpes simplex keratitis (HSK) is a common cause of corneal blindness.
- Latanoprost is a prostaglandin analog widely used to treat glaucoma.
Observation:
- Three cases of HSK developing after initiating latanoprost therapy are presented.
- Recurrence of HSK was observed upon latanoprost reintroduction in one patient.
Findings:
- Latanoprost treatment was associated with HSK recurrence in patients with a history of the condition.
- Discontinuation of latanoprost led to HSK resolution, while its reintroduction caused recurrence, even with antiviral prophylaxis.
Implications:
- Prostaglandins, potentially mediated by latanoprost, may stimulate HSK recurrence.
- Clinicians should consider the potential association between latanoprost and HSK when managing patients with a history of herpetic eye disease.