Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phylogenetic perspectives in innate immunity.

J A Hoffmann1, F C Kafatos, C A Janeway

  • 1Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France. jhoff@ibmc.u-strasbg.fr

Science (New York, N.Y.)
|May 21, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The selection of self-MHC recognizing T lymphocytes: a role for idiotypes?

Immunology today·2014
Same author

T-cell regulation of IgA responses.

Immunology today·2014
Same author

Through a glass, darkly ….

Immunology today·2014
Same author

Quantitative variation in la antigen expression plays a central role in immune regulation.

Immunology today·2014
Same author

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.

Immunogenetics·2012
Same author

The immunological system of the child: part I: development of immunity in the child.

Archives of disease in childhood·2010

Innate immunity provides early host defense against infection. Similarities in Drosophila and mammals suggest common ancestry, with innate immunity also priming adaptive immunity.

Area of Science:

  • Immunology
  • Evolutionary Biology
  • Microbiology

Background:

  • Innate immunity is the initial host defense against pathogens.
  • Recent findings reveal conserved mechanisms between Drosophila and mammals.
  • This suggests an evolutionary link in immune responses.

Purpose of the Study:

  • To explore the evolutionary conservation of innate immunity.
  • To highlight similarities in pathogen recognition and signaling.
  • To understand the role of innate immunity in initiating adaptive immunity.

Main Methods:

  • Comparative analysis of innate immune pathways in Drosophila and mammals.
  • Review of recent research on pathogen recognition and signaling.
  • Examination of the interplay between innate and adaptive immunity.

Related Experiment Videos

Main Results:

  • Significant similarities identified in pathogen recognition, signaling pathways, and effector mechanisms.
  • Evidence supports a common evolutionary origin for innate immune defenses.
  • Innate immunity in mammals is crucial for activating adaptive immunity.

Conclusions:

  • Innate immunity is a conserved defense system across species.
  • Understanding innate immunity provides insights into host-pathogen interactions.
  • The link between innate and adaptive immunity is fundamental to host defense.