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Updated: Aug 27, 2026
Mouse Round Spermatid Injection
Published on: January 26, 2024
A retrospective follow-up study on intracytoplasmic sperm injection
R Van Golde1, M Boada, A Veiga
1Reproductive Medicine Service, Institut Universitari Dexeus, Barcelona, Spain.
Purpose:
Genetic aspects of male subfertility and the novelty of intracytoplasmic sperm injection (ICSI) as a new technique can influence the development of zygotes and children born after ICSI. Therefore, we evaluated the outcome of ICSI compared to in vitro fertilization (IVF).
Methods:
Data from medical records of 233 total pregnancies and the follow-up of 132 children born after IVF and 120 after ICSI were retrospectively analyzed.
Results:
No differences were found between ICSI and IVF for early embryonic development and obstetric outcome. In both groups the rate of women undergoing prenatal chromosomal diagnosis was low, 30.0%. The congenital malformation rate was 3.0% after IVF and 1.7% after ICSI, which was not significantly different. Follow-up on development of children born after IVF and ICSI also showed no significant differences.
Conclusions:
Our results indicate that at this moment ICSI is a safe procedure. However, a consistent prospective follow-up is still mandatory to exclude possible risks.
