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Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis
H Zouali1, L Faure-Delanef, G Lucotte
1Centre d'Etude du Polymorphisme Humain, Paris, France.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 21, 1999
Summary
Genetic analysis of the apolipoprotein C-II gene in French multiple sclerosis (MS) patients revealed significant differences in microsatellite allele frequencies compared to controls, suggesting a potential role in MS susceptibility.
Area of Science:
- Genetics
- Neuroimmunology
- Human Population Genetics
Background:
- Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
- Genetic factors are known to contribute to MS susceptibility.
- The apolipoprotein C-II (APOC2) gene region is a potential candidate for MS genetic influence.
Purpose of the Study:
- To investigate the association between a specific microsatellite marker in the APOC2 gene and MS.
- To analyze allelic frequencies of the (TG)n(AG)m marker in French MS patients and healthy controls.
Main Methods:
- Polymerase Chain Reaction (PCR) based method was employed for microsatellite analysis.
- Allelic frequencies of the (TG)n(AG)m marker in the first intron of the APOC2 gene were determined.
- Samples from 74 MS patients and 102 controls were analyzed.
Main Results:
- A significant difference in microsatellite allele distribution was observed between MS patients and controls (chi^2 = 7.82, P < 0.04).
- Increased frequency of allele 6 was noted in MS patients.
- A decreased frequency of allele I was observed in MS patients (P < 0.03).
Conclusions:
- The APOC2 gene region, specifically the analyzed microsatellite marker, shows a significant association with multiple sclerosis.
- Allelic variations within the APOC2 gene may influence susceptibility to MS in the studied French population.
- Further research into the APOC2 gene's role in MS pathogenesis is warranted.