Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variations among non-sedating antihistamines: are there real differences?

M J Mattila1, I Paakkari

  • 1Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland.

European Journal of Clinical Pharmacology
|May 21, 1999
PubMed
Summary

Modern non-sedating antihistamines offer improved allergy relief with fewer central nervous system effects. However, individual sensitivity and drug interactions can still cause sedation, and some carry cardiac risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute effect of antipyretic analgesics, alone or in combination with alcohol, on human psychomotor skills related to driving.

British journal of clinical pharmacology·2012
Same author

Effects of psychotropic drugs on digit substitution: comparison of the computerized symbol-digit substitution and traditional digit-symbol substitution tests.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Objective and subjective effects of remoxipride, alone and in combination with ethanol or diazepam, on performance in healthy subjects.

Journal of psychopharmacology (Oxford, England)·2011
Same author

[New anti-inflammatory analgetics--are they needed?].

Duodecim; laaketieteellinen aikakauskirja·2002
Same author

Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.

Inflammation·2002
Same author

[Nitric oxide in the exhaled air--a new indicator of asthmatic airway inflammation].

Duodecim; laaketieteellinen aikakauskirja·2002

Area of Science:

  • Pharmacology
  • Allergy and Immunology

Background:

  • Older antihistamines often caused significant central nervous system (CNS) sedation and antimuscarinic side effects.
  • Newer non-sedating H1 receptor antagonists (antihistamines) were developed to minimize these effects.
  • Despite improvements, some newer antihistamines may still cause sedation and possess cardiotoxic potential.

Purpose of the Study:

  • To review the properties of modern non-sedating H1 receptor antagonists.
  • To discuss their efficacy in treating allergic conditions.
  • To highlight potential central effects and cardiotoxicity risks.

Main Methods:

  • Review of available literature on H1 receptor antagonists.
  • Analysis of clinical studies and pharmacological data.

Related Experiment Videos

  • Comparison of sedative and cardiotoxic profiles of various antihistamines.

    • Main Results:

    • Most modern antihistamines penetrate the brain poorly, reducing central effects.
    • Individual patient factors and drug interactions can lead to unexpected sedation.
    • Certain antihistamines (astemizole, terfenadine) carry a risk of cardiac dysrhythmias.

    Conclusions:

    • Non-sedating antihistamines provide effective allergy treatment with a better safety profile than older drugs.
    • Caution is advised regarding potential sedation and cardiac risks, especially with specific drug interactions.
    • Glucocorticoids are preferred for long-term itching management over sedating antihistamines.