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Stratum corneum chymotryptic enzyme in psoriasis.

E Ekholm¹, T Egelrud

¹Department of Dermatology, University Hospital, Umeå, Sweden. elisabeth.ekholm@dermven.umu.se

Archives of Dermatological Research

|May 21, 1999

Summary

Stratum corneum chymotryptic enzyme (SCCE) expression is increased in psoriatic lesions. This enzyme, potentially involved in skin turnover and inflammation, exists in both active and inactive forms in psoriatic scales.

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Area of Science:

Dermatology
Biochemistry
Enzymology

Background:

Stratum corneum chymotryptic enzyme (SCCE) is a serine protease implicated in skin barrier function.
SCCE may play a role in epidermal cytokine activation, such as interleukin-1beta.
Its precise function in skin homeostasis and disease requires further investigation.

Purpose of the Study:

To investigate SCCE expression patterns in psoriatic epidermis using immunohistochemistry.
To characterize the biochemical nature of SCCE in psoriatic scales.
To explore the potential role of SCCE in psoriasis pathophysiology.

Main Methods:

Immunohistochemistry was employed to assess SCCE expression in psoriatic lesions and normal skin.
Biochemical analyses, including zymography and immunoblotting, were used to study SCCE in psoriatic scales.
Enzyme inhibitor studies were conducted to confirm SCCE activity.

Main Results:

Psoriatic lesions showed a consistent increase in SCCE-expressing cell layers compared to normal skin.
SCCE expression patterns varied in nonlesional psoriatic skin, with some exhibiting increased SCCE.
Psoriatic scales contained both active SCCE and its inactive precursor, confirmed by biochemical assays.

Conclusions:

SCCE expression appears upregulated in psoriasis.
The conversion of inactive SCCE precursor to active SCCE occurs within psoriatic lesions.
The specific role of SCCE in the pathophysiology of psoriasis warrants further research.

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