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Related Experiment Videos

Giant papillary conjunctivitis--a review.

C H Katelaris1

  • 1Department of Clinical Immunology & Allergy, Westmead Hospital, Sydney, Australia.

Acta Ophthalmologica Scandinavica. Supplement
|May 25, 1999
PubMed
Summary
This summary is machine-generated.

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Giant Papillary Conjunctivitis (GPC) is an allergic eye condition often linked to contact lens wear. Improved lens hygiene and disposable lenses have reduced its incidence.

Area of Science:

  • Ophthalmology
  • Allergic Diseases

Background:

  • Giant Papillary Conjunctivitis (GPC) is an external ocular allergic condition.
  • First described in 1974, GPC is commonly associated with contact lens wear, ocular prostheses, or corneal sutures.

Purpose of the Study:

  • To describe the clinical presentation, diagnosis, and management of Giant Papillary Conjunctivitis.
  • To discuss the immunological basis and contributing factors to GPC.

Main Methods:

  • Clinical observation and patient history.
  • Ocular examination for conjunctival hyperaemia and enlarged tarsal papillae.
  • Review of histopathological similarities with Vernal Keratoconjunctivitis (VKC).

Main Results:

  • Patients report decreased lens tolerance, mucus production, blurred vision, and itching.

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  • Diagnosis is confirmed by characteristic conjunctival changes.
  • The incidence of GPC has declined with the adoption of disposable contact lenses.

    • Conclusions:

    • GPC management involves patient education on lens hygiene, with options for disposable lenses or cessation of wear.
    • Pharmacological treatments may be necessary in severe cases.
    • GPC results from a complex immune response involving trauma and foreign body reactions, not solely IgE-mediated.