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Eosinophilic pustular folliculitis in infancy: report of two new cases

M Larralde1, S Morales, A Santos Muñoz

  • 1Department of Pediatric Dermatology, Ramos Mejía Hospital, Buenos Aires, Argentina.

Pediatric Dermatology
|May 25, 1999
PubMed

Insights

Eosinophilic pustular folliculitis (EPF) presents as itchy, pustular lesions. While often self-limiting, it can lead to severe infections like sepsis, but responds to topical corticosteroids.

Area of Science:

  • Dermatology
  • Immunology
  • Infectious Diseases

Background:

  • Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin condition affecting hair follicles.
  • Its exact cause is unknown, and diagnosis relies on clinical and histopathological examination.
  • EPF can present with recurrent, itchy, papular, and pustular lesions on the face, trunk, and extremities.

Observation:

  • Two patients experienced recurrent EPF episodes lasting approximately one month with intermittent remissions.
  • Patient 1 developed sepsis with lung and liver involvement due to methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.
  • Patient 2 had no identifiable infectious or parasitic cause for their EPF.

Findings:

  • Histological examination revealed a mixed inflammatory infiltrate rich in eosinophils around the hair follicles in both patients.
  • Despite the potential for superinfection, as seen in Patient 1, EPF is generally considered a self-limited dermatosis.
  • Both patients showed significant improvement with topical corticosteroid treatment.

Implications:

  • This case series highlights the potential for severe complications, including sepsis, in patients with Eosinophilic pustular folliculitis.
  • Early diagnosis and management are crucial, considering both inflammatory and infectious components.
  • Topical corticosteroids remain an effective treatment modality for managing EPF symptoms.

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