Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat

A W Burton1, D H Lee, C Saab

  • 1Department of Anesthesiology, University of Texas Medical Branch, Galveston 77555-0591, USA.

Regional Anesthesia and Pain Medicine
|May 25, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Screening for diabetic retinopathy by non-mydriatic fundus photography: First national campaign in Lebanon].

Journal francais d'ophtalmologie·2019
Same author

Relation of the Mediterranean diet with the incidence of gestational diabetes.

European journal of clinical nutrition·2013
Same author

When do we need central nervous system prophylaxis in patients with extranodal NK/T-cell lymphoma, nasal type?

Annals of oncology : official journal of the European Society for Medical Oncology·2009
Same author

Magnesium sulphate has beneficial effects as an adjuvant during general anaesthesia for Caesarean section.

British journal of anaesthesia·2009
Same author

Excessive toxicity of once daily i.v. BU, melphalan and thiotepa followed by auto SCT on patients with non-Hodgkin's lymphoma.

Bone marrow transplantation·2009
Same author

Small but powerful: short peptide hormones and their role in autoimmune inflammation.

Journal of neuroimmunology·2009
Same journal

Association between Ehlers-Danlos syndrome and complex regional pain syndrome: a large nationwide claims database study.

Regional anesthesia and pain medicine·2026
Same journal

Author's reply to: "Interpreting the link between vitamin D deficiency and postoperative pain after breast cancer surgery".

Regional anesthesia and pain medicine·2026
Same journal

Balancing machine learning with human application: the importance of interpretability and context.

Regional anesthesia and pain medicine·2026
Same journal

New persistent opioid use following surgery among opioid-naïve patients in the USA: a systematic review and meta-analysis of observational studies.

Regional anesthesia and pain medicine·2026
Same journal

Sensory innervation of the knee joint: a narrative review of articular branch mapping and sensory receptor distribution.

Regional anesthesia and pain medicine·2026
Same journal

Pilot study of feasibility, acceptability, and changes in clinical outcomes following a brief trauma-focused intervention for chronic pain.

Regional anesthesia and pain medicine·2026
See all related articles

Preemptive intrathecal ketamine significantly reduced neuropathic pain behaviors in rats for two weeks. This N-Methyl-D-Aspartate receptor antagonist offers a promising approach for managing chronic pain.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Ketamine is an N-Methyl-D-Aspartate (NMDA) receptor antagonist with established efficacy in treating somatic and neuropathic pain.
  • Preemptive analgesia aims to prevent the establishment of central sensitization and subsequent chronic pain development.

Purpose of the Study:

  • To investigate the efficacy of preemptive ketamine administration for neuropathic pain.
  • To compare the effects of intrathecal versus intraperitoneal ketamine administration routes.

Main Methods:

  • Thirty male Sprague-Dawley rats underwent surgery to induce neuropathic pain via spinal nerve ligation.
  • Animals were divided into three groups: control (saline), intrathecal ketamine (ITK), and intraperitoneal ketamine (IPK).
  • Pain behaviors (mechanical allodynia, cold allodynia, ongoing pain) were assessed postoperatively using von Frey, acetone, and cold plate tests.

Related Experiment Videos

Main Results:

  • Intrathecal ketamine (ITK) significantly reduced mechanical allodynia, cold allodynia, and ongoing pain behaviors compared to controls.
  • These analgesic effects were sustained for at least two weeks post-administration.
  • Intraperitoneal ketamine (IPK) demonstrated intermediate efficacy between the control and ITK groups.

Conclusions:

  • Preemptive intrathecal ketamine administration effectively reduces neuropathic pain behaviors for at least two weeks.
  • The findings suggest that preventing spinal cord sensitization is a key mechanism of action.
  • Intrathecal administration appears more effective than intraperitoneal for preemptive neuropathic pain management.