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Related Experiment Videos

Naevus-associated melanomas: cause or chance?

D Massi1, P Carli, A Franchi

  • 1Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze, Italy.

Melanoma Research
|May 25, 1999
PubMed
Summary

Approximately 20% of melanomas show an associated melanocytic naevus, with distinct clinicopathological profiles. This suggests a potential causal link, though collision events are also possible. The classification of naevus remnants showed good interobserver reliability.

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • The relationship between melanocytic naevi and melanoma is debated.
  • Understanding this association is crucial for melanoma diagnosis and management.

Purpose of the Study:

  • To determine the incidence of melanocytic naevi associated with melanoma.
  • To compare clinicopathological profiles of melanomas with (MN+) and without (MN-) an associated naevus.
  • To assess interobserver reliability in classifying naevus remnants.

Main Methods:

  • Histopathological evaluation of 131 invasive melanoma cases (thickness ≤4 mm, Clark's level
  • Analysis of associated melanocytic naevus presence, clinicopathological features, and naevus type (congenital vs. acquired).
  • Interobserver reliability assessment for naevus classification.

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Main Results:

  • A melanocytic naevus was associated with 20.6% of melanomas.
  • Melanomas with associated naevi (MN+) were more frequent in males and on the trunk.
  • No significant differences in histotype, Clark's level, or thickness were found between MN+ and MN-.
  • Interobserver concordance for classifying naevus remnants was high (81.4%, kappa=0.78).

Conclusions:

  • While most melanomas arise de novo, a significant proportion (approx. 20%) are associated with a melanocytic naevus.
  • Different clinicopathological profiles of MN+ and MN- suggest a potential causal relationship in some cases.
  • Histopathological criteria for distinguishing congenital and acquired naevi demonstrate good reproducibility.