Related Experiment Video
Updated: Jun 22, 2026

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
Published on: July 21, 2017
Lipolysis, fatness, gender and plasma leptin concentrations in healthy, normal-weight subjects
B Morio1, A M Gachon, Y Boirie
1Laboratoire de Nutrition Humaine, Centre de Recherche en Nutrition, Humaine-Auvergene, Clermont-Ferrand, France. morio@clermont.inra.fr
Background:
Relationship between plasma leptin and adiposity and gender has been reported in adults. Effects of age on plasma leptin is unclear and regulation of leptin production by white adipose tissue is still poorly understood.
Objectives:
To study if age and parameters of lipolysis are related to plasma leptin concentrations.
Methods:
Seventy-seven healthy, normal-weight subjects (age range 19-82 y.) had measurements of body composition (18oxygen dilution technique) and of fasting plasma levels of leptin, glycerol, and nonesterified fatty acids (NEFA).
Results:
Plasma leptin was correlated to NEFA (r = 0.28) and glycerol (r = 0.48) concentrations. The relationship between %fat and plasma leptin was best fitted by an exponential (r2 = 0.82). In multiple regression %fat, body mass index, glycerol, and gender, but not fat mass, age or NEFA contributed independently to the variation in log plasma leptin. Log plasma leptin was higher in women than in men for a given glycerol concentration.
Conclusion:
Adiposity, lipolysis, and gender are related to plasma leptin in healthy humans.
Related Concept Videos
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation
Considering cholesterol and...
Obesity
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

