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Multiple sclerosis: experience in neuroimaging era from western India
1Department of Neurology, KEM Hospital, Parel, Mumbai, 400012, India.
Neurology India
|May 26, 1999
Summary
This study on multiple sclerosis (MS) in India found a clinical pattern similar to Asian cases, with visual loss and motor weakness as common symptoms. Findings highlight the need for localized understanding of MS epidemiology and presentation.
Area of Science:
- Neurology
- Epidemiology
Background:
- Multiple Sclerosis (MS) is a demyelinating disease with varied epidemiology globally.
- Understanding regional variations in MS presentation is crucial for diagnosis and management.
Purpose of the Study:
- To analyze the clinical characteristics, incidence, and diagnostic findings of multiple sclerosis (MS) in Western India.
- To compare the Indian MS cohort with existing Asian and Western data.
Main Methods:
- Retrospective review of 31 patients diagnosed with MS over six years at a teaching hospital.
- Analysis of clinical presentation, age at onset, and diagnostic investigations including MRI and CSF immuno-globulins.
Main Results:
- Hospital incidence of MS was 0.85% of neurology admissions, comparable to other Indian studies.
- Common symptoms included visual loss (47%) and motor weakness (27%), with a female preponderance and higher incidence of Devic's syndrome.
- MRI scans showed high abnormality rates (24/25 brain, 15/16 spine), and 80% of patients had elevated CSF immuno-globulins.
Conclusions:
- The clinical pattern of MS in this Indian cohort aligns more closely with Asian rather than Western series.
- Findings underscore the importance of considering regional epidemiological and clinical differences in multiple sclerosis.