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Systemic brucellosis with chronic meningitis: A case report.

D Ghosh1, P Gupta, S Prabhakar

  • 1Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, U.T., 160012, India.

Neurology India
|May 26, 1999
PubMed
Summary

A rare case of Brucellosis in a young adult presented with prolonged fever, headache, and vomiting. Prompt treatment with a combination of antibiotics led to complete recovery and normalized cerebrospinal fluid findings.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Brucellosis is a zoonotic infection that can affect multiple organ systems.
  • Neurological involvement in Brucellosis, while reported, is uncommon, particularly in young adults.

Observation:

  • A young adult male experienced an 11-month history of debilitating symptoms including fever, headache, and vomiting.
  • Cerebrospinal fluid (CSF) analysis revealed lymphocytic pleocytosis with elevated protein levels, suggesting central nervous system inflammation.
  • Serological testing showed a high titer for Brucella in serum (1:320), with a weaker positive result in CSF.

Findings:

  • The patient demonstrated a significant clinical and CSF response to a combination antibiotic regimen including tetracycline, rifampicin, and streptomycin.

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  • The neurological presentation and subsequent recovery highlight the importance of considering Brucellosis in the differential diagnosis of unexplained CNS inflammation.
  • Implications:

    • This case underscores the diagnostic challenge of neurobrucellosis, especially with atypical presentations.
    • Effective treatment can lead to complete resolution of neurological symptoms and CSF abnormalities.
    • Highlights the need for increased awareness among clinicians regarding the diverse manifestations of Brucellosis.