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Related Experiment Videos

Copper associated acute hepatic failure in a dog.

L J Noaker1, R J Washabau, C J Detrisac

  • 1Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.

Journal of the American Veterinary Medical Association
|May 26, 1999
PubMed
Summary

A Dalmatian dog with vomiting and weight loss was diagnosed with copper storage disease. Despite treatment, the dog

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Area of Science:

  • Veterinary Pathology
  • Canine Hepatology
  • Toxicology

Background:

  • Copper storage disease is a genetic disorder affecting liver function.
  • Dalmatians are predisposed to certain metabolic disorders.

Observation:

  • A 1.5-year-old Dalmatian presented with vomiting, weight loss, and elevated liver enzymes.
  • Histopathology revealed centrilobular hepatocyte necrosis and copper accumulation.
  • Abdominal ultrasonography showed normal hepatic echogenicity.

Findings:

  • Rubeanic acid staining confirmed copper pigment in macrophages and hepatocytes.
  • High hepatic copper concentration was measured.
  • The dog's condition worsened despite treatment with fluids, antibiotics, and a low-copper diet.

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Implications:

  • This case highlights the importance of considering copper storage disease in Dalmatians with liver dysfunction.
  • Early diagnosis and specific chelation therapy may improve outcomes.
  • Further research into genetic predispositions for copper toxicosis in dogs is warranted.