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Hepatic angiosarcomas in dogs: an excessive frequency as compared with man
Journal of the National Cancer Institute
|August 1, 1976
Summary
Canine liver angiosarcomas are more common in certain breeds and show no sex predilection. These tumors share histological similarities with human hepatic angiosarcomas but occur with much higher frequency in dogs.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Angiosarcomas are malignant vascular tumors.
- Hepatic angiosarcomas occur in the liver.
- Canine cancers are an important area of comparative oncology research.
Purpose of the Study:
- To describe the characteristics of hepatic angiosarcomas in dogs.
- To investigate potential breed or sex predispositions.
- To compare canine hepatic angiosarcomas to human counterparts.
Main Methods:
- Retrospective case series analysis.
- Review of 18 reported cases of canine liver angiosarcoma.
- Histopathological comparison with human hepatic angiosarcomas.
Main Results:
- Identified 18 cases of canine liver angiosarcoma from veterinary schools.
- Suggested potential breed predispositions for this tumor.
- Found no significant sex predilection.
- Observed histological similarities between canine and human hepatic angiosarcomas.
- Noted a significantly higher relative frequency in dogs compared to humans (25-100 times).
Conclusions:
- Certain dog breeds may be predisposed to liver angiosarcoma.
- Canine liver angiosarcoma is a significant comparative model for human disease.
- Further research into breed-specific risk factors is warranted.