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Design and semisynthesis of spermine-sensitive Ribonuclease S'
I Hamachi1, Y Yamada, R Eboshi
1Department of Chemistry & Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki, Fukuoka, Japan.
Bioorganic & Medicinal Chemistry Letters
|May 26, 1999
Abstract:
Spermine-sensitive stabilization of semisynthetic Ribonuclease S' was successfully carried out by sequence specific incorporation of a poly-anion domain into alpha-helix region of S-peptide.