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Inhibition of human telomerase by PNA-cationic peptide conjugates
J G Harrison1, C Frier, R Laurant
1Department of Chemistry, University of Cambridge, UK.
Bioorganic & Medicinal Chemistry Letters
|May 26, 1999
Abstract:
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.