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Updated: Aug 1, 2026
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The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Tli1, a resistance locus for carcinogen-induced T-lymphoma
A Wielowieyski1, L A Brennan, J Jongstra
1University of Toronto Arthritis Centre of Excellence at the Toronto Hospital and Arthritis and Immune Disorder Research Centre and Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5T 2S8.
Summary
A specific gene locus, T-lymphoma Induced 1 (Tli1), on chromosome 1 significantly influences susceptibility to N-methyl-N-nitrosourea (MNU)-induced T-lymphoma in mice. The BALB/cJ allele of Tli1 appears to suppress lymphoma development.
Area of Science:
- Immunology
- Genetics
- Oncology
Background:
- N-methyl-N-nitrosourea (MNU) is a chemical mutagen that induces T-lymphoma in mice.
- Genetic background significantly impacts susceptibility to MNU-induced T-lymphoma, with AKR/J mice being highly susceptible and BALB/cJ mice less so.
Purpose of the Study:
- To identify genetic loci associated with susceptibility to MNU-induced T-lymphoma.
- To characterize the inheritance pattern and potential function of identified susceptibility loci.
Main Methods:
- Genome-wide linkage analysis in a cross between susceptible AKR/J and resistant BALB/cJ mice treated with MNU.
- Fine mapping of the identified locus using congenic mouse strains.
- Analysis of allele frequencies in tumor-bearing and tumor-free mice.
Main Results:
- A major quantitative trait locus, T-lymphoma Induced 1 (Tli1), was identified on chromosome 1.
- The BALB/cJ allele of Tli1 (Tli1b) was found to be recessive and suppressive of MNU-induced T-lymphoma development, particularly late-onset lymphomas.
- Candidate genes within the Tli1 locus include IL10 and Cmkar4.
Conclusions:
- Tli1 is a key genetic determinant of susceptibility to MNU-induced T-lymphoma in mice.
- The Tli1b allele confers resistance by suppressing lymphoma development.
- Further investigation into IL10 and Cmkar4 is warranted to elucidate the mechanism of Tli1-mediated suppression.
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