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Human gastrointestinal tolerance to D-tagatose
B Buemann1, S Toubro, A Astrup
1Research Department of Human Nutrition & Centre of Food Research, Royal Veterinary and Agricultural University, Frederiksberg, 1958, Denmark. BBU@KVL.DK
Regulatory Toxicology and Pharmacology : RTP
|May 26, 1999
Summary
D-Tagatose, a low-calorie sweetener, may cause gastrointestinal issues like diarrhea and nausea. Doses of 30g may be too high for regular consumption due to these side effects.
Area of Science:
- Nutrition Science
- Gastroenterology
Background:
- D-Tagatose, a D-fructose stereoisomer, is poorly absorbed, suggesting potential as a reduced-calorie sweetener.
- Malabsorbed sugars can cause gastric discomfort due to osmotic effects in the gut.
Purpose of the Study:
- To evaluate the gastrointestinal effects of consuming D-tagatose.
- To determine the incidence of adverse symptoms associated with D-tagatose intake.
Main Methods:
- Gastrointestinal symptoms were recorded in 73 healthy young males after consuming 29 or 30g of D-tagatose.
- A screening study and subsequent studies monitored symptoms like nausea, diarrhea, and flatulence.
Main Results:
- Nausea (15.1%) and diarrhea (31.5%) were reported in the screening study.
- Increased flatulence was frequently observed and persisted even with daily 30g intake over 15 days.
- Most symptoms were mild to moderate.
Conclusions:
- Consumption of 30g of D-tagatose at one time may exceed recommended dosage levels due to associated gastrointestinal discomfort.
- Further research may be needed to establish safe and tolerable intake levels for D-tagatose as a sweetener.