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[Partial thromboplastin time (PTT) in the pediatric age group. Normal values and changes under different storage
Insights
Pediatric partial thromboplastin time (PTT) values are age-dependent, with infants under 0.5 years having longer PTT-times. Blood storage up to 10 hours did not affect PTT results.
Area of Science:
- Pediatric Hematology
- Clinical Coagulation Studies
Context:
- Establishing normal reference ranges for coagulation tests is crucial for pediatric patient care.
- Previous studies on partial thromboplastin time (PTT) in children have yielded varying results.
- The PTT-reagent used can influence obtained values.
Purpose:
- To determine normal partial thromboplastin time (PTT) values in infants and children.
- To investigate the influence of age and sex on PTT in pediatric populations.
- To compare obtained PTT values with existing literature and assess the impact of short-term blood storage.
Summary:
- This study established normal PTT values in 60 infants and children (3 days to 14 years) with normal preoperative coagulation and no bleeding complications.
- Infants under 0.5 years exhibited significantly longer PTT-times (mean 37.65 sec) compared to older children (mean 32.72 sec).
- No significant differences were observed based on sex, and PTT remained stable after 6-10 hours of whole blood storage at room temperature.
Impact:
- Provides age-specific normal PTT reference ranges for pediatric patients.
- Highlights potential discrepancies with existing literature, possibly due to reagent differences.
- Suggests that short-term blood sample storage does not significantly alter PTT results in this age group.
Abstract:
Normal values for PTT were obtained from 60 infants and children- age 3 days to 14 years- who had unremarkable preoperative coagulation tests and had tolerated surgical procedures without bleeding complications. The 27 infants, who were less than 0.5 years old, had significantly longer PTT-times (mean value 37.65 sec., extreme values 29.6-47.4 sec) than the older children (mean value: 32.72 sec., extreme values: 24.9-40.5 sec). These results, which were obtained with PTT-reagent ROCHE, are considerably shorter than comparable values in the literature. There were no differences in the values from boys or girls. No positive correlation between PTT and bleeding time were found. There were no significant changes of PTT when the whole blood had been stored at room temperature (22-25 degrees C) for 6 to 10 hours before it was tested.