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[Corticosteroid therapy in atopic diseases of children? (author's transl)]
Insights
Corticosteroid therapy in children with atopic diseases frequently causes side effects. Prolonged topical corticosteroid use in atopic dermatitis led to irreversible body changes, particularly in girls.
Area of Science:
- Pediatric Dermatology
- Allergy and Immunology
Context:
- Study analyzed 416 pediatric patients with atopic diseases at a German clinic.
- Investigated the prevalence and impact of corticosteroid therapy in this cohort.
Purpose:
- To assess the incidence of side effects from corticosteroid therapy in children with atopic diseases.
- To examine the long-term consequences of topical corticosteroid treatment for atopic dermatitis.
Summary:
- 69.2% of patients had prior corticosteroid therapy, with 81.9% experiencing adverse dermatological effects.
- Prolonged topical corticosteroid use resulted in irreversible body changes via transcutaneous absorption.
- These changes were more pronounced in female patients.
Impact:
- Highlights the risks associated with corticosteroid use in pediatric atopic conditions.
- Underscores the need for cautious and monitored application of topical corticosteroids in children.
- Suggests potential gender-based differences in the absorption and effects of these treatments.
Abstract:
Of 416 children suffering from different atopic diseases who were admitted as in-patients in a German aero-biological childrens clinic, 69.2% had previously received corticosteroid therapy. According to dermatological findings, 81.9% of these patients developed undesirable side effects. Of the children whose atopic dermatitis was treated prolonged with topical corticosteroids, also irreversible body changes developed through the transcutaneous absorptive processes, which were more evident and appeared more often in girls than in boys.