Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The p53 pathway.

C Prives1, P A Hall

  • 1Department of Biological Sciences, Columbia University, New York 10027, USA.

The Journal of Pathology
|May 26, 1999
PubMed
Summary
This summary is machine-generated.

The p53 tumor suppressor gene is frequently altered in cancers. This review highlights recent p53 research, focusing on signaling pathways, protein interactions, and downstream targets for potential clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus.

Oncogene·2018
Same author

Cognitive effects of a 30-min aerobic exercise bout on adults with overweight/obesity and type 2 diabetes.

Obesity science & practice·2017
Same author

Primary Gut Lymphomas.

Leukemia & lymphoma·2016
Same author

Peripheral T Cell Lymphoma: an Overview.

Leukemia & lymphoma·2016
Same author

A capabilities approach to population health and public policy-making.

Revue d'epidemiologie et de sante publique·2013
Same author

Food safety objective approach for controlling Clostridium botulinum growth and toxin production in commercially sterile foods.

Journal of food protection·2011
Same journal

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology·2026
Same journal

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

The Journal of pathology·2026
Same journal

Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.

The Journal of pathology·2026
Same journal

FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma.

The Journal of pathology·2026
Same journal

Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

The Journal of pathology·2026
Same journal

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

The Journal of pathology·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Abnormalities in the p53 tumor suppressor gene are common in various cancers.
  • p53 is a highly studied protein with extensive existing literature.

Purpose of the Study:

  • To review recent developments in p53 research.
  • To contextualize new findings within modern models of p53 function.
  • To emphasize the need for integrating different research approaches for clinical application.

Main Methods:

  • Focused review of selected recent p53 literature.
  • Analysis of signaling pathways, including phosphorylation cascades.
  • Examination of protein-protein interactions (e.g., mdm2, ARF) and downstream target identification.

Related Experiment Videos

Main Results:

  • Recent progress in understanding p53 signaling pathways.
  • Insights into p53's interactions with regulatory proteins like mdm2 and ARF.
  • Discussion of strategies for identifying p53's downstream targets and the biology of p53 homologues.

Conclusions:

  • Integrating reductionist studies with biological and genetic analyses is crucial.
  • Bridging the gap between basic research and clinical application is necessary for effective cancer care.
  • Further research into p53 and its homologues can inform cancer treatment strategies.