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Shiftwork and myocardial infarction: a case-control study.

A Knutsson¹, J Hallquist, C Reuterwall

¹Department of Occupational and Environmental Medicine, Umeå University Hospital, Sweden.

Occupational and Environmental Medicine

|May 26, 1999

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Shiftwork increases the risk of myocardial infarction (MI) in both men and women. This association persists regardless of job strain, smoking, or education level, suggesting shiftwork itself is a significant risk factor for heart disease.

Area of Science:

Cardiology
Occupational Health
Epidemiology

Background:

Previous studies suggest a link between shiftwork and coronary heart disease.
Job strain may mediate or interact with shiftwork to influence disease development.

Purpose of the Study:

To investigate the relationship between shiftwork, job strain, and myocardial infarction.
To determine if job strain mediates or interacts with shiftwork in myocardial infarction risk.

Main Methods:

A population-based case-control study comparing 2006 myocardial infarction cases with 2642 controls.
Analysis considered factors including job strain, age, education, and smoking.

Main Results:

Shiftwork was associated with increased myocardial infarction risk in both men (OR 1.3) and women (OR 1.3).

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Elevated risk was observed in the 45-55 age group (men: 1.6, women: 3.0).

The association could not be explained by job strain, age, education, or smoking; no interaction was found.

Conclusions:

Shiftwork is independently associated with myocardial infarction in both genders.
The underlying mechanism remains unclear, as job strain, smoking, and education do not explain the observed relationship.