Related Experiment Video
Updated: Aug 11, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Long-term efficacy of humalog in subjects with Type 1 diabetes mellitus
S K Garg1, J H Anderson, S V Perry
1Barbara Davis Center for Childhood Diabetes, Department of Paediatrics, University of Colorado Health Sciences Center, Denver, USA. Satish.Garg@UCHSC.edu
Aims:
To evaluate the long-term effectiveness of Humalog insulin in lowering post meal glucose excursions.
Methods:
Twenty young subjects with Type 1 diabetes mellitus (DM) who had received insulin-lispro (Humalog) for a least 1 year (mean +/- SD 1.8+/-1.6 years) were studied on two occasions, 3-14 days apart. They consumed a similar breakfast consisting of 450-600 kCal having fasted overnight. The same amount of human soluble Humulin Regular or Humalog insulin was given 10 min before the meal in a randomized, double-blind fashion.
Results:
Postprandial glucose excursions at 30, 60, and 120 min were significantly lower (P<0.001, ANCOVA) when subjects received Humalog as compared to human soluble insulin. Serum-free insulin levels were significantly higher (P<0.001, ANOVA) at 30 and 60 min when subjects received Humalog as compared with human soluble insulin. Humalog antibody levels after up to 5.4 years of receiving Humalog insulin were not elevated beyond the values at 1 year.
Conclusions:
We conclude that Humalog insulin is effective in lowering postprandial glucose excursions even after up to 5.4 years of treatment.
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into rapid-acting...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Oral Hypoglycemic Agents: Glinides
Type I Diabetes III: Clinical Manifestations
Type II Diabetes II: Pathophysiology
