Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GABAergic cell types in the lizard hippocampus.

S Guirado1, J C Dávila

  • 1Department of Cell Biology, University of Málaga, Spain. guirado@uma.es

European Journal of Morphology
|May 26, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light microscopy of the medial wall of the cerebral cortex of the lizard Psammodromus algirus.

Journal of morphology·2018
Same author

Electron microscopy of the medial cortex in the lizard Psammodromus algirus.

Journal of morphology·2018
Same author

Electron microscopy of the dorsomedial cortex in the lizard Psammodromus algirus.

Journal of morphology·2018
Same author

A golgi study of the dorsal cortex in the lizard Psammodromus algirus.

Journal of morphology·2018
Same author

Effect of lipopeptides of antagonistic strains of Bacillus subtilis on the morphology and ultrastructure of the cucurbit fungal pathogen Podosphaera fusca.

Journal of applied microbiology·2007
Same author

Expression of calcium-binding proteins in the diencephalon of the lizard Psammodromus algirus.

The Journal of comparative neurology·2000

Researchers classified GABAergic cells in the lizard hippocampus into four subtypes. These subtypes target specific locations on principal neurons, offering new insights into hippocampal circuitry and inhibitory neurotransmission.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Neuroanatomy

Background:

  • GABAergic cells are crucial for regulating neuronal activity in the hippocampus.
  • Understanding the diversity and targets of these cells is key to deciphering hippocampal function.

Purpose of the Study:

  • To neurochemically classify GABAergic cells in the lizard hippocampus.
  • To identify the specific synaptic targets of each GABAergic cell subtype on principal neurons.

Main Methods:

  • Neurochemical analysis of GABAergic cells in lizard hippocampus.
  • Identification of specific molecular markers (e.g., GABA, neuropeptides, calretinin, parvalbumin, calbindin, NADPH-diaphorase).
  • Synaptic target mapping on principal hippocampal neurons.

Related Experiment Videos

Main Results:

  • Four distinct, non-overlapping GABAergic cell subtypes were identified.
  • GABA/neuropeptide subtype synapses target distal apical dendrites.
  • Calretinin- and parvalbumin-containing subtypes synapse on cell bodies and proximal dendrites.
  • Calbindin-expressing interneurons target dendrites.
  • A subtype with NADPH-diaphorase activity was identified, but its synaptic target remains unknown.

Conclusions:

  • The lizard hippocampus exhibits a complex organization of GABAergic interneurons.
  • Specific subtypes target distinct compartments of principal neurons, suggesting specialized roles in circuit modulation.
  • Further research is needed to elucidate the function of the NADPH-diaphorase-positive subtype.