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Related Experiment Videos

Increased cutaneous immunoreactive stem cell factor expression and serum stem cell factor level in systemic

C Kihira1, H Mizutani, K Asahi

  • 1Department of Dermatology, Mie University, Faculty of Medicine, Japan.

Journal of Dermatological Science
|May 26, 1999
PubMed
Summary
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Stem cell factor (SCF) is elevated in systemic sclerosis (SSC) skin and serum, correlating with itching and hyperpigmentation. SCF may drive mast cell and melanocyte activation in SSC.

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Systemic sclerosis (SSC) presents with characteristic skin symptoms like itching and hyperpigmentation.
  • Stem cell factor (SCF), also known as c-kit ligand, is a cytokine involved in melanocyte and mast cell development.

Purpose of the Study:

  • To investigate the expression of SCF in normal and SSC skin.
  • To compare tissue SCF expression with serum SCF levels in different phases of SSC.
  • To elucidate the role of SCF in SSC pathogenesis, specifically in relation to itching and hyperpigmentation.

Main Methods:

  • Histopathological analysis of SCF expression in normal and SSC forearm skin.
  • Quantification of serum SCF levels using enzyme-linked immunosorbent assay (ELISA).

Related Experiment Videos

  • Correlation of SCF expression patterns with clinical phases of SSC (edematous, sclerotic, atrophic).

    • Main Results:

    • Epidermal and dermal SCF expression was significantly higher in the edematous phase of SSC compared to normal skin.
    • Tissue SCF expression decreased in later phases (sclerotic and atrophic), approaching normal levels.
    • Serum SCF levels were elevated in the edematous phase, further increased in the sclerotic phase, and decreased in the atrophic phase, remaining above normal levels.

    Conclusions:

    • Dermal SCF expression correlates with itching and mast cell increase in the edematous phase of SSC.
    • Elevated serum SCF levels may contribute to hyperpigmentation observed in the sclerotic and atrophic phases of SSC.
    • Fibroblast-associated SCF likely promotes dermal mast cell development, while soluble serum SCF may activate melanocytes in SSC.