Related Experiment Video
Updated: Oct 21, 2026

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
Published on: May 24, 2011
Complement-mediated regulation of Trichomonas vaginalis infection in mice
P Caterina1, D Lynch, R B Ashman
1Department of Anatomical Pathology, The Western Australian Centre for Pathology and Medical Research, Western Australia. Paul.Caterina@health.wa.gov.au
Abstract:
Trichomonas vaginalis is a flagellated protozoan which causes trichomoniasis, a sexually transmitted disease of the human genitourinary tract. The importance of the alternative complement pathway in host defence against T. vaginalis was investigated in vitro. Kinetic studies utilising immunofixation following electrophoresis showed that both a strongly and weakly virulent strain of T. vaginalis activated murine serum C3. In vivo studies with congenic-resistant, C5-deficient, B10.D2/OSn- and C5-sufficient, B10.D2/nSn mice showed that the presence of C5 is a significant factor in the innate host resistance to primary infection with a strongly virulent, but not a weakly virulent trichomonad strain.
Related Concept Videos
Trichomoniasis
Microbiota of the Urogenital Tract
