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Updated: Aug 9, 2026
12:05
Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
Published on: March 6, 2013
Selenocysteine-containing proteins in mammals
1Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA. vng@unlinfo2.unl.edu
Journal of Biomedical Science
|May 27, 1999
Summary
Selenium biology has expanded with the discovery of selenocysteine, the 21st amino acid. This review covers known mammalian selenoproteins and their crucial roles in human health.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- The discovery of selenocysteine as the 21st amino acid has significantly advanced selenium biology.
- Twelve mammalian selenoproteins have been identified, each incorporating selenocysteine via specific UGA codons.
Purpose of the Study:
- To review known mammalian selenoproteins.
- To discuss recent advancements and future research directions in selenium biology.
Main Methods:
- Literature review of selenoprotein research.
- Analysis of selenoprotein structure-function relationships.
Main Results:
- Selenocysteine is found at the active centers of known selenoproteins, explaining selenium's importance in health.
- Diverse cellular functions are associated with different selenoproteins.
Conclusions:
- Selenoproteins play vital roles in human health and development.
- Continued research into selenium biology promises further insights into health and disease.
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