Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anti-thrombocyte antibodies].

A von Felten

    Schweizerische Medizinische Wochenschrift
    |October 2, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Platelets can be targets of antibodies or bind immune complexes, potentially causing thrombocytopenia. Immune reactions may also lead to compensated states or functional platelet defects, not always low platelet counts.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic predisposition to bleeding during oral anticoagulant therapy: evidence for common founder mutations (FIXVal-10 and FIXThr-10) and an independent CpG hotspot mutation (FIXThr-10).

    Thrombosis and haemostasis·2001
    Same author

    Opposite effects of lornoxicam co-administration on phenprocoumon pharmacokinetics and pharmacodynamics.

    European journal of clinical pharmacology·1999
    Same author

    No clinically relevant effect of lornoxicam intake on acenocoumarol pharmacokinetics and pharmacodynamics.

    European journal of clinical pharmacology·1999
    Same author

    [Subcutaneous hematomas, reduced Quick value. Factor VII deficiency].

    Praxis·1998
    Same author

    Antibodies against platelet glycoproteins and antiphospholipid antibodies in autoimmune thrombocytopenia.

    European journal of haematology·1998
    Same author

    Is heparin therapy necessary in CAPD peritonitis?

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·1997
    Same journal

    Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Boeck's disease as a tuberculous syndrome.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Enteral primary tubercular complexes

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    Tuberculous stenoses of the large bronchi.

    Schweizerische medizinische Wochenschrift·2010
    Same journal

    About the enzyme action.

    Schweizerische medizinische Wochenschrift·2010
    See all related articles

    Area of Science:

    • Immunology
    • Hematology
    • Platelet biology

    Context:

    • Platelets play a role in immune responses.
    • Distinguishing mechanisms of antiplatelet antibody action is challenging.
    • Thrombocytopenia is a common finding in autoimmune diseases.

    Purpose:

    • To explore the dual role of platelets in immune reactions.
    • To investigate the causes of thrombocytopenia in autoimmune diseases.
    • To differentiate between immune complex-mediated and direct antiplatelet antibody effects.

    Summary:

    • Platelets can be direct targets of antiplatelet antibodies or act as receptors for immune complexes.
    • Current clinical tests often fail to distinguish these two mechanisms.
    • This ambiguity suggests immune complexes may be a significant cause of thrombocytopenia in autoimmune conditions.

    Related Experiment Videos

    Impact:

    • Clarifies the complex interplay between platelets and the immune system.
    • Highlights limitations in current diagnostic methods for antiplatelet antibodies.
    • Provides a framework for understanding "compensated thrombocytolytic states" and "immunologic thrombocytopathy".