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Applying the Sheffield tables to data from general practice.

J Muir1, A Fuller, T Lancaster

  • 1General Practice Research Group, University of Oxford.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
|May 27, 1999
PubMed
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Statin drugs lower cholesterol and reduce coronary event risk. The Sheffield tables identify high-risk individuals, with 3% of men and 0.05% of women exceeding the threshold, primarily older smokers.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Pharmacology

Background:

  • Cardiovascular disease remains a leading cause of mortality globally.
  • Statins are a widely prescribed class of drugs for lowering cholesterol.
  • Current guidelines advocate for risk-based statin therapy initiation.

Purpose of the Study:

  • To evaluate the application of the Sheffield tables in a general practice cohort.
  • To identify the proportion of individuals exceeding the 3% 10-year coronary event risk threshold.
  • To assess the demographic characteristics of individuals recommended for statin therapy.

Main Methods:

  • Retrospective analysis of a general practice cohort aged 35-68 years.
  • Application of the Sheffield tables to estimate the absolute risk of a first coronary event.

Related Experiment Videos

  • Stratification of results by age, sex, and smoking status.

    • Main Results:

    • 3% of men and 0.05% of women were identified as candidates for statin therapy based on the Sheffield tables.
    • Individuals aged over 50 who smoked constituted 85% of those recommended for treatment.
    • Smoking cessation was associated with a significant reduction in coronary event risk, potentially bringing most smokers below the treatment threshold.

    Conclusions:

    • The Sheffield tables identify a small but significant proportion of individuals eligible for statin therapy in primary care.
    • Smoking is a major modifiable risk factor driving statin recommendations in older adults.
    • Smoking cessation interventions could substantially decrease the number of individuals requiring pharmacological cholesterol management.