Identifying inner retinal contributions to the human multifocal ERG
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Updated: Oct 21, 2026

Multifocal Electroretinograms
Published on: December 4, 2011
D C Hood1, V Greenstein, L Frishman
1Department of Psychology, Columbia University, New York, NY 10027, USA. don@psych.columbia.edu
Abstract:
Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.
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