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Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp
T Kagamizono1, T Hamaguchi, T Ando
1The Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
The Journal of Antibiotics
|May 27, 1999
Abstract:
Phosphatoquinones A and B were isolated from the cultured broth of Streptomyces sp. TA-0363 and their structures were elucidated by spectroscopic analyses. Phosphatoquinones A and B inhibited the protein tyrosine phosphatase activity prepared from human Ball-1 cells with IC50 of 28 microM and 2.9 microM, respectively.