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Structural elucidation of a novel erythromycin, 13-cyclopentyl-13-desethyl-erythromycin B, from a recombinant

I C Parsons1, J R Everett, M S Pacey

  • 1Department of Physical Sciences, Pfizer Central Research, Sandwich, Kent, UK.

The Journal of Antibiotics
|May 27, 1999
PubMed
Abstract

No abstract available in PubMed .

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Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...

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