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Related Experiment Videos

Correlation between preoperative predictors and pathologic features in radical prostatectomy specimens in PSA-based

W Horninger1, H Rogatsch, A Reissigl

  • 1Department of Urology, University of Innsbruck, Austria.

The Prostate
|May 27, 1999
PubMed
Summary

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Upgrading of Gleason score 6 prostate cancers on biopsy after prostatectomy in the low and intermediate tPSA range.

Prostate cancer and prostatic diseases·2009

High total PSA and low percent free PSA levels indicate more aggressive prostate cancer. These markers aid clinicians in choosing the best treatment for patients diagnosed via PSA screening.

Area of Science:

  • Urology
  • Oncology
  • Biomarker Research

Background:

  • Prostate-specific antigen (PSA) screening improves prostate cancer detection specificity.
  • Percent free PSA, PSA density, and PSA-transition zone density enhance screening accuracy.
  • These markers predict pathologic features in radical prostatectomy specimens.

Purpose of the Study:

  • Evaluate total PSA, percent free PSA, PSA density, and PSA-TZ density.
  • Correlate these markers with pathologic findings in prostatectomy specimens.
  • Assess predictive ability for aggressive cancer features.

Main Methods:

  • Correlated pre-diagnosis PSA marker levels with 102 radical prostatectomy findings.
  • Utilized histological examination of entire prostate organs.

Related Experiment Videos

  • Employed Pearson correlation coefficients for statistical analysis.

    • Main Results:

    • High total PSA, PSA density, and PSA-TZ density correlated with capsular penetration, high Gleason scores, and large cancer volumes.
    • Percent free PSA correlated with high Gleason scores, high cancer percentages, and large cancer volumes, but not capsular penetration.
    • Logistic regression identified percent free PSA and total PSA as significant predictors of Gleason scores ≥7 and cancer volumes ≥0.5 cc; percent free PSA and biopsy Gleason score predicted clinically insignificant cancers.

    Conclusions:

    • High total PSA with low percent free PSA suggests more aggressive prostate cancer in PSA-screened men.
    • These findings assist clinicians and patients in selecting optimal therapeutic strategies.
    • Biomarker combinations improve risk stratification for prostate cancer management.