Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet function testing by flow cytometry.

H M Rinder1

  • 1Hematology Laboratories, Yale-New Haven Hospital, New Haven CT, USA.

Clinical Laboratory Science : Journal of the American Society for Medical Technology
|May 27, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.

Journal of thrombosis and haemostasis : JTH·2010
Same author

The effects of heparin, protamine, and heparin/protamine reversal on platelet function under conditions of arterial shear stress.

Anesthesia and analgesia·2001
Same author

Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production.

Blood·2001
Same author

Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy?

Drug and alcohol dependence·2000
Same author

Hemosiderosis in a normal child secondary to oral iron medication.

Pediatrics·2000
Same author

Optimal dosing and triggers for prophylactic use of platelet transfusions.

Current opinion in hematology·1999
Same journal

Evaluation of Diverse Health Professionals' Learning Experience in a Continuing Education Activity for Quality Practices in Molecular Genetic Testing.

Clinical laboratory science : journal of the American Society for Medical Technology·2019
Same journal

Guidelines for Initiating a Research Agenda: Research Design and Dissemination of Results.

Clinical laboratory science : journal of the American Society for Medical Technology·2015
Same journal

Guidelines for Initiating a Research Agenda: Topic Selection and Evidence of Impact.

Clinical laboratory science : journal of the American Society for Medical Technology·2015
Same journal

Autonomy and Privacy in Clinical Laboratory Science Policy and Practice.

Clinical laboratory science : journal of the American Society for Medical Technology·2015
Same journal

The Value of Clinical Laboratory Sciences Research.

Clinical laboratory science : journal of the American Society for Medical Technology·2015
Same journal

From Technical Assistants to Critical Thinkers: From World War II to 2014.

Clinical laboratory science : journal of the American Society for Medical Technology·2015
See all related articles

Flow cytometry offers advanced methods to analyze platelet function, including receptor expression and activation status. This review outlines literature using these techniques for in vivo and ex vivo platelet studies.

Area of Science:

  • Hematology
  • Immunology
  • Biotechnology

Background:

  • Flow cytometry is a powerful technique for analyzing cell populations.
  • Platelets play a crucial role in hemostasis and thrombosis.
  • Understanding platelet function is vital for diagnosing and treating various diseases.

Purpose of the Study:

  • To provide an overview of flow cytometry applications in platelet function analysis.
  • To highlight the utility of fluorescent probes and monoclonal antibodies in platelet research.
  • To review literature examining both in vivo and ex vivo platelet behavior.

Main Methods:

  • Utilizing fluorescent monoclonal antibodies and probes for flow cytometry.
  • Assessing platelet glycoprotein receptor expression (resting and stimulated).

Related Experiment Videos

  • Measuring intracellular calcium flux and adhesion ligand binding.

    • Main Results:

    • Flow cytometry enables detailed analysis of platelet activation markers.
    • Techniques can evaluate granule secretion and neoantigen expression.
    • Studies demonstrate flow cytometry's capability to assess platelet aggregation and microparticle formation.

    Conclusions:

    • Flow cytometry is an indispensable tool for comprehensive platelet function analysis.
    • This methodology facilitates detailed investigation of platelet responses in various physiological and pathological conditions.
    • The reviewed literature showcases the broad applicability of flow cytometry in platelet research.