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Two auronols from Pseudolarix amabilis.

X C Li1, H N ElSohly, A C Nimrod

  • 1National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.

Journal of Natural Products
|May 29, 1999
PubMed
Summary
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Two new auronols were isolated from Pseudolarix amabilis bark. Pseudolaric acid B showed significant antimicrobial activity against Candida albicans.

Area of Science:

  • Natural Products Chemistry
  • Pharmacognosy
  • Medicinal Chemistry

Background:

  • Pseudolarix amabilis is a traditional medicinal plant.
  • The bark of P. amabilis contains various bioactive compounds.

Purpose of the Study:

  • To isolate and characterize new compounds from P. amabilis bark.
  • To evaluate the antimicrobial potential of isolated compounds.

Main Methods:

  • Phytochemical investigation of P. amabilis bark.
  • Structure elucidation using spectral data (NMR, MS).
  • Antimicrobial activity assays (MIC, MFC).

Main Results:

  • Two new auronols, amaronols A and B, were identified.
  • Eight compounds were isolated, including known pseudolaric acids and myricetin.

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  • Pseudolaric acid B demonstrated potent activity against Candida albicans.
  • Myricetin showed marginal activity against Trichophyton mentagrophytes.

    • Conclusions:

    • Amaronols A and B are novel compounds from P. amabilis.
    • Pseudolaric acid B possesses significant antifungal properties.
    • P. amabilis bark is a valuable source of bioactive natural products.